Health

Coronavirus | Hopes rise for Oxford vaccine

Bringing relief: The Oxford-AstraZeneca vaccine is likely to be rolled out in the first half of 2021. File   | Photo Credit: Reuters

The COVID-19 experimental vaccine, developed by the University of Oxford, also triggers lower adverse responses among the elderly as well as young adults, British drug maker AstraZeneca Plc, which is helping manufacture the vaccine, said on Monday.

A vaccine that works is seen as a game-changer in the battle against the novel coronavirus, which has killed more than 1.15 million people worldwide, shuttered swathes of the global economy and turned normal life upside down for billions of people.

Also read: Coronavirus | AstraZeneca COVID-19 vaccine trial Brazil volunteer dies, trial to continue

“It is encouraging to see immunogenicity responses were similar between older and younger adults and that reactogenicity was lower in older adults, where the COVID-19 disease severity is higher,” an AstraZeneca spokesman said.

“The results further build the body of evidence for the safety and immunogenicity of AZD1222,” the spokesman said, referring to the technical name of the vaccine.

Also read: Coronavirus | Vaccine shot ‘painless’, say Covishield trial volunteers

AstraZeneca did not provide details of the data behind the statement or say when it would publish eagerly awaited late-stage phase III trial data, which would show whether the vaccine works well enough in large scale trials for it to be approved.

The Oxford/AstraZeneca vaccine is expected to be one of the first from big pharma to secure regulatory approval, along with Pfizer and BioNTech's candidate.

Also read: Coronavirus | Trials of a dozen vaccines progressing, says Gagandeep Kang

The news that older people get an immune response from the vaccine is positive because the immune system weakens with age and older people are those most at risk of dying from the virus.

British Health Secretary Matt Hancock said a vaccine was not yet ready but he was preparing logistics for a possible roll out mostly in the first half of 2021.

Asked if some people could receive a vaccine this year he told the BBC: “I don't rule that out but that is not my central expectation.”

Work began on the Oxford vaccine in January. Called AZD1222 or ChAdOx1 nCoV-19, the viral vector vaccine is made from a weakened version of a common cold virus that causes infections in chimpanzees.

Immunogenicity blood tests carried out on a subset of older participants echo data released in July which showed the vaccine generated “robust immune responses” in a group of healthy adults aged between 18 and 55, the Financial Times reported earlier.

“We need to see the data before concluding that the responses were 'similar',” Stephen Evans, a professor of pharmacoepidemiology at London School of Hygiene & Tropical Medicine, said.

He said that reactogenecity, which refers to common side-effects of vaccines like soreness and redness of the arm, was “often, but not always” associated with a vaccine’s immunogenicity.

“Studies carried out in the first stage of development of a vaccine will result in choosing a dose that does not cause too much reactogenicity,” he said.

Also read: Oxford University’s coronavirus vaccine opens for clinical trial on humans

AstraZeneca has signed several supply and manufacturing deals with companies and governments around the world as it gets closer to reporting early results of a late-stage clinical trial.

It resumed the U.S. trial of the experimental vaccine after approval by U.S. regulators, the company said on Friday.

Staff at a London hospital trust have been told to be ready to receive the first batches of the Oxford/AstraZeneca vaccine, The Sun newspaper reported on Monday.

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Printable version | Dec 2, 2020 9:29:14 AM | https://www.thehindu.com/sci-tech/health/oxford-vaccine-prompts-immune-response-in-elderly-pharma/article32947424.ece

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