China halts work by team on gene-edited babies

November 29, 2018 07:16 pm | Updated 07:16 pm IST

In this Oct. 10, 2018, photo, scientist He Jiankui speaks during an interview in Shenzhen in southern China's Guandong province. China's government on Thursday, Nov. 29, 2018, ordered a halt to work by a medical team that claimed to have helped make the world's first gene-edited babies.

In this Oct. 10, 2018, photo, scientist He Jiankui speaks during an interview in Shenzhen in southern China's Guandong province. China's government on Thursday, Nov. 29, 2018, ordered a halt to work by a medical team that claimed to have helped make the world's first gene-edited babies.

Chinese Vice Minister of Science and Technology Xu Nanping told state broadcaster CCTV that his ministry is strongly opposed to the efforts that reportedly produced twin girls born earlier this month. Mr. Xu called the team’s actions illegal and unacceptable and said an investigation had been ordered, but made no mention of specific actions taken.

Researcher He Jiankui had claimed to have altered the DNA of the twins to try to make them resistant to infection with the AIDS virus. Mainstream scientists condemned the experiment, and universities and government groups are currently investigating.

A group of leading scientists gathered in Hong Kong this week for an international conference on gene editing, the ability to rewrite the code of life to try to correct or prevent diseases.

Although the science holds promise for helping people already born and studies testing that are underway, a statement issued on Thursday by the 14-member conference leaders said it was irresponsible to try it on eggs, sperm or embryos except in lab research because not enough is known yet about its risks or safety.

The conference was rocked by the Chinese researcher’s claim to have helped make the world’s first gene-edited babies. Conference leaders called for an independent investigation of the claim by Mr. He, who spoke to the group on Wednesday as international criticism of his claim mounted .

There is no independent confirmation of Mr. He’s claims. He was scheduled to speak again at the conference on Thursday, but he left Hong Kong and through a spokesman, sent a statement saying, “I will remain in China, my home country, and cooperate fully with all inquiries about my work. My raw data will be made available for third party review.”

Several prominent scientists said the case showed a failure of the field to police itself and the need for stricter principles or regulations.

“It’s not unreasonable to expect the scientific community” to follow guidelines, said David Baltimore, a Nobel laureate from California Institute of Technology, who led the panel.

There already are some rules that should have prevented what Mr. He says he did, said Alta Charo, a University of Wisconsin lawyer and bioethicist and a conference organizer.

“I think the failure was his, not the scientific community,” Ms. Charo said.

Gene editing for reproductive purposes might be considered in the future “but only when there is compelling medical need,” with clear understanding of risks and benefits, and certain other conditions, said Dr. Victor Dzau, president of the U.S. National Academy of Medicine, one of the conference sponsors.

“Not following these guidelines would be an irresponsible act,” he added.

Other sponsors of the three-day conference are the Academy of Sciences of Hong Kong, the Royal Society of the United Kingdom and the U.S. National Academy of Sciences and U.S. National Academy Sciences.

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