Premier League title chasers Manchester City and Manchester United slumped to Europa League last 16 first-leg defeats on Thursday as Spain celebrated three wins out of three.
The results:At Lisbon: Sporting Lisbon 1 (Xandao 51) bt Manchester City 0.
At Enschede: FC Twente 1 (de Jong 61-pen) bt Schalke 04 0.
At Madrid: Atletico Madrid 3 (Salvio 24, 27, Adrian 37) bt Besiktas 1 (Simao 53).
At Kharkiv: Metalist Kharkiv 0 lost to Olympiakos 1 (Fuster 50).
At London: Manchester United 2 (Rooney 22, 90+2-pen) lost to Athletic Bilbao 3 (Llorente 44, de Marcos 72, Muniain 90).
At Liege: Standard Liege 2 (Buyens 27, Tchite 30) drew with Hanover 2 (Stindl 22-pen, Diouf 56).
At Valencia: Valencia 4 (Victor Ruiz 11, Soldado 13, 43-pen, Piatti 56) bt PSV Eindhoven 2 (Toivonen 83-pen, Wijnaldum 90).
At Alkmaar: AZ Alkmaar 2 (Martens 63, Falkenburg 84) bt Udinese 0.
