Teenager Moise Kean scored his sixth goal in as many games but champion Juventus slumped to a shock 2-1 defeat at SPAL on Saturday to put its Serie A title celebrations on hold.
Massimiliano Allegri's side had needed just a point to claim a 35th Scudetto with a record six games to spare and Napoli a distant second.
Kean opened for the scoring for the visitors when the 19-year-old stuck his foot out to direct a Juan Cuadrado effort into goal after half an hour in Ferrara.
But Kevin Bonifazi (49) and Sergio Floccari (74) came back with precious goals which eased SPAL's fight for top-flight football next season.
Juventus has a 20-point advantage on Napoli and can still seal the title on Sunday if Carlo Ancelotti's side fails to win at bottom club Chievo.
No team has ever won the title so early.
The previous best was five games to spare achieved by Torino in 1947-1948, Fiorentina in 1955-1956 and Roberto Mancini's Inter Milan in 2006-2007.
Tottenham moves up
Tottenham shrugged off the loss of Harry Kane as Lucas Moura's hat-trick moved Spurs up to third in the Premier League with a 4-0 win over Huddersfield, while Cardiff slipped closer to relegation after going down 2-0 at Burnley.
Victor Wanyama opened the scoring on 24 minutes to allay any fears that Tottenham might suffer a European hangover.
Lucas made it 2-0 three minutes later and then struck twice more in the final three minutes as Pochettino's men made it three wins.
And Pochettino was delighted to see his side rack up the score in the final stages with goal difference potentially pivotal come the end of the season.
While the title and fight for Champions League places look set to go down to the wire, the relegation battle could be all but over should Brighton beat Cardiff on Tuesday.
The Welsh side is still five points adrift of safety after a controversial defeat at Turf Moor.
Chris Wood gave the hosts a deserved half-time lead, but Cardiff was left furious after referee Mike Dean overruled his assistant's decision to award a penalty to the visitors after the break.
Another big Cardiff penalty appeal was turned down before Wood sealed the win in stoppage time.
The results:Premier League : Leicester 0 lost to Newcastle 1 (Perez 32); Tottenham 4 (Wanyama 24, Lucas Moura 27, 87, 90+3) bt Huddersfield 0; Brighton 0 lost to Bournemouth 5 (Gosling 33, Fraser 55, Brooks 74, Wilson 82, Stanislas 90+2), Burnley 2 (Wood 31, 90+2) bt Cardiff 0; Fulham 2 (Cairney 46, Babel 69) bt Everton 0; Southampton 3 (Redmond 2, 30, Long 71) bt Wolves 1 (Boly 28.
Bundesliga : Nuremberg 1 (Kubo 81) drew with Schalke 1 (Nastasic 84)
Leipzig 2 (Kampl 16, Werner 28) bt Wolfsburg 0; Stuttgart 0 lost to Bayer Leverkusen 1 (Havertz 64-pen); Werder Bremen 2 (Klaassen 77, Gebre Selassie 84) bt Freiburg 1 (Waldschmidt 90+3); Hanover 0 lost to Borussia Moenchengladbach 1 (Raffael 53).
La Liga: Espanyol 2 (Pedrosa 19, Laguardia Cisneros 47-og) bt Alaves 1 (Calleri 56); Huesca 0 drew with Barcelona 0.
Serie A: SPAL 2 (Bonifazi 49, Floccari 74) bt Juventus 1 (Kean 30).
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