Cancer cell detection ‘dots’ developed from coal in Assam

Costs one-twentieth of imported carbon quantum dots (CQDs).

June 19, 2019 10:09 pm | Updated 10:09 pm IST - GUWAHATI

Binoy K. Saikia, second from right, in the lab with coal and carbon quantum dots (inset).

Binoy K. Saikia, second from right, in the lab with coal and carbon quantum dots (inset).

A team of scientists in Assam has developed a chemical process that turns ‘dirty’ coal into a biomedical ‘dot’ to help detect cancer cells.

The team, led by Binoy Kumar Saikia and Tonkeswar Das, has applied for a patent for their chemical method of producing carbon quantum dots (CQDs) from cheap, abundant, low-quality and high-sulphur coals.

CQDs are carbon-based nanomaterials whose size is less than 10 nm, or nanometre.

“Carbon-based nanomaterials are used as diagnostic tools for bio-imaging, especially in detecting cancer cells, for chemical sensing and in opto-electronics. A few chemical companies in the U.S. and Japan have been manufacturing CQDs. What we have done is develop fluorescent carbon nanomaterials at one-twentieth the cost of imported CQDs,” Mr. Saikia told The Hindu on Wednesday.

He is a scientist in the Polymer Petroleum and Coal Chemistry Group of the Council of Scientific & Industrial Research-North East Institute of Science and Technology (CSIR-NEIST) in eastern Assam’s Jorhat, about 300 km from Guwahati.

The CQDs that the CSIR-NEIST team developed emit a bluish colour with “high-stability, good-conductivity, low-toxicity, environmental friendliness, and good optical properties”. The finer details have been published in their study published in the Journal of Photochemistry and Photobiology .

“Our source material is abundant, low-quality Indian coal not directly suitable for thermal electricity production. Even if the selling price is twice our cost of production of ₹50 per ml, it will be much cheaper than the imported CQDs with market price of up to ₹2,000 per ml,” he said.

Scientists said CQDs are futuristic materials whose demand in India has been increasing leading to a considerable volume of import. The CSIR-NEIST technology can produce approximately 1 litre of CQDs per day at a low cost to become an import substitute.

Other advantages of the process are the use of environment-friendly reagents and less water than methods elsewhere. The process can also be recycled with a manageable supply chain, the scientists said.

The other members of the team that developed the “blue fluorescent and biocompatible carbon dots derived from abundant low-quality coals” are H.P. Dekaboruah, Manobjyoti Bordoloi, Dipankar Neog, Jayanta J.Bora, Jiumoni Lahkar, Bardwi Narzary, Sonali Roy, and Danaboyina Ramaiah.

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