Scientists from University of California, Irvine, have suggested that a new therapy may soon help restore limb function long after the injury in stroke patients.
The researchers discovered a naturally-occurring protein in humans that has been found to restore motor function in rats after a stroke. When administered directly to the brain, the protein appeared to restore 99 percent of lost movement and if given through the nose, 70 percent of lost movement is regained. Moreover, untreated rats improved by only 30 percent.
“No drugs exist that will help a stroke after a few days. If you have a stroke, you don’t have many treatment options,” said James Fallon, psychiatry & human behavior professor and senior co-author of the studies. “Now we have evidence there may be therapies that can repair damage to a significant degree long after the stroke. It’s a completely unexpected and remarkable finding, and it’s worth trying in humans,” Fallon added.
Lead researcher Magda Guerra-Crespo chronicles the success of a small protein called transforming growth factor alpha, which plays critical tissue-forming and developmental roles in humans from just after conception through birth and into old age.
“TGF alpha has been studied for two decades in other organ systems but never before has been shown to reverse the symptoms of a stroke,” Guerra-Crespo said. Scientists sought to learn whether TGF alpha administered directly to the brain could help rats with stroke-induced loss of limb function, typically on one side — as is seen in humans.
When injected with with TGF alpha, the stroke-induced rats regained nearly all their motor function, while those rats that did not receive treatment improved just 30 percent.
“It’s becoming more and more clear that the brain is like any other organ: It has a lot of potential to regenerate,” said Darius Gleason, a developmental & cell biology graduate student who worked on the study. “We are just emulating nature by giving a little nudge to what the brain is trying to do itself,” Gleason added. The study appears in journal Neuroscience.