Probability of survival decreases with increased duration of CPR Premium

A new study published in the journal The BMJ Open has found that a person’s chance of surviving while receiving cardiopulmonary resuscitation (CPR) for cardiac arrest in a hospital declines rapidly from 22% after one minute to less than 1% after 39 minutes. Similarly, the likelihood of leaving the hospital with no major brain damage declines from 15% after one minute of CPR to less than 1% after 32 minutes with no heartbeat. The researchers say the findings provide insights that may help guide hospital teams, patients and their families in deciding how long to continue resuscitation.

In-hospital cardiac arrest is a common and catastrophic medical emergency, with only around 25% of patients surviving to hospital discharge. Studies have shown that a longer resuscitation time for patients with in-hospital cardiac arrest is linked to lower odds of survival, but experts have been unable to make specific recommendations on when to stop resuscitation.

To address this knowledge gap, researchers measured the effect of CPR duration (in minutes) on outcomes for 348,996 U.S. adults (average age 67 years) who had an in-hospital cardiac arrest between 2000 and 2021.

CPR was defined as the interval between the start of chest compression and the first return of spontaneous circulation (ROSC) or termination of resuscitation.

The main measures of interest were survival to hospital discharge and favourable functional outcome at hospital discharge, defined as a brain performance score of one (good cerebral performance) or two (moderate cerebral disability) on a five-point scale.

After accounting for potentially influential factors such as age, sex, ethnicity, and a range of pre-existing conditions, the results show that of the 348,996 patients, 233,551 (67%) achieved return of spontaneous circulation with an average CPR duration of seven minutes, whereas 115,445 (33%) did not achieve return of spontaneous circulation with an average CPR duration of 20 minutes. At one minute’s CPR duration, the probabilities of survival and favourable functional outcome among patients were 22% and 15%, respectively.

But as duration of CPR increased, the probabilities of survival and favourable functional outcome decreased to less than 1% for survival at 39 minutes and less than 1% for favorable functional outcome at 32 minutes.