Christian Pulisic pulled the strings and Jozy Altidore grabbed a brace as the United States overran Panama 4-0 in Orlando on Friday to leave them on the verge of automatic qualification for next year's World Cup finals in Russia.
The victory lifted the United States into third place in the six-team CONCACAF group, above Panama, who started the day a point ahead of them.
A win in their final match against Trinidad and Tobago will likely be enough to see the United States through as Honduras would need to win both their remaining games and overturn a goal difference currently at 12.
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Top team Mexico are already through from the North, Central American and Caribbean Confederation and second-placed Costa Rica need just a point from their final two matches to join them.
Costa Rica's scheduled qualifier with Honduras on Friday in San Jose was postponed until Saturday due to severe rainfall caused by tropical storm Nate.
The top three teams qualify automatically, while the fourth-placed side goes into a play-off against a team from the Asian confederation.
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Pulisic got the opener after eight minutes when he sprinted free of the defence and slotted the ball home from a tight angle after rounding the goalkeeper.
Altidore made it two 11 minutes later when he side-footed home an inviting low cross from Pulisic. The burly striker made it 3-0 just seconds before half time when he chipped home a penalty after Bobby Wood was upended in the box.
Wood got the goal his play deserved 18 minutes into the second half when he spun inside the box and fired past goalkeeper Jaime Penedo.
The United States should have scored more but profligate finishing and a fine performance from Penedo kept the score down.