Scientists claim to have carried out a pioneering stem cell transplant that rebuilt brain circuitry in mice, an achievement which could pave the way for a new and effective treatment for conditions from Parkinson’s to autism.
In their experiment, an international team, led by Harvard University, put healthy stem cells from mouse embryos into the brains of adult laboratory rodents who were unable to use leptin, a hormone that tells the body to stop eating.
The transplant worked to the extent that the creatures were able to process leptin again -- and duly lost weight.
The researchers said they studied obesity only because it would be obvious whether the experiment had worked. Their true target in treating a critical region of the brain was complex conditions such as Parkinson’s, autism, epilepsy, motor neuron disease and spinal cord injuries.
The “blank” stem cells turned into four types of neuron, or brain cell, and connected up with existing cells, say the scientists whose findings have been published in the latest edition of the ‘Science’ journal.
Jeffery Macklis at Harvard University, who led the team, was quoted by the ‘Daily Mail’ as saying, “We’ve used complex circuitry as a test case for whether precisely selected and controlled neuron transplants could rewire the brain.
“What we found is these neurons not only turned into the right types of cells, but they sent signals to the recipient’s brain and received signals from the recipient’s brain.
“The next step for us is to ask parallel questions of other parts of the brain and spinal cord, those involved in ALS (motor neuron disease) and with spinal cord injuries.
Can we rebuild circuitry in the mammalian brain? I suspect that we can.”