Clue to neurodegenerative disease

The disease mechanism for adult-onset progressive degenerative diseases begins much earlier than previously thought, according to a study published in the Journal of Clinical Investigation. Using a mouse model of spinocerebellar ataxia type 1 (SCA1), genetically engineered to precisely mirror the human disease, a team of investigators showed that there is an altered neural circuitry in the cerebellum that sets the stage for later disease vulnerability. These findings are important as they raise the possibility that other adult-onset neurodegenerative diseases have their roots in early developmental defects, with implications for pathogenesis and treatment. It is reportedly the first discovery of alterations in an adult-onset spinocerebellar disorder that stem from such early developmental processes and could be extended to a whole host of other diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis.

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Printable version | Jan 28, 2021 2:21:50 PM |

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