The litchi link?: on Bihar encephalitis deaths

The death of over 90 children in about a month in Muzaffarpur district of north Bihar due to low blood sugar level could have easily been prevented with some foresight and early care. Six years ago, a two-member team invited by the State government suspected that a toxin (methylenecyclopropylglycine, MCPG, also known as hypoglycin A) naturally present in litchi fruit was responsible for the mysterious deaths; a large Indo-U.S team confirmed it in 2017. The two-member team found that undernourished children who ate the fruit during the day and went to bed on an empty stomach presented with serious illness early the next morning. In 2014, the team saved 74% of sick children through a simple intervention — infusing 10% dextrose within four hours of the onset of illness. The recommended prevention strategy — making sure that no child goes to bed without eating a meal — adopted from 2015 ensured a sharp drop in the number of children falling sick. It is appalling that this year the government failed to raise awareness on this strategy. Worse, some doctors came up with alternative explanations for the illness and even pointed to the heat wave.

While the most common causes of acute encephalitis syndrome are traced to a bacteria or a virus and it takes at least a few days before presenting serious symptoms and deaths, the toxin in litchi causes serious problems overnight. While well-nourished children who eat the fruit remain unaffected even if they go to bed on an empty stomach, the under-nourished ones are at grave risk. Blood glucose falls sharply causing severe brain malfunction (encephalopathy), leading to seizures and coma, and death in many cases. This is because under-nourished children lack sufficient glucose reserve in the form of glycogen and the production of glucose from non-carbohydrate source is blocked midway leading to low blood sugar level. This causes serious brain function derangement and seizures. While 5% dextrose infusion serves the purpose in cases of general low blood sugar, children suffering from acute hypoglycaemic encephalopathy can be saved only by infusing 10% dextrose within four hours of illness onset. Recovery is rapid and complete if 10% dextrose is infused within the golden hours. Infusing a higher concentration of dextrose is necessary to completely stop the attempt by the body to produce glucose from non-carbohydrate source. If encephalopathy was indeed the cause of death, this simple medical intervention could have saved many lives. Dextrose infusion could have been done even as children were being transported to hospitals in ambulances. The failures were at the stages of both prevention and care.

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Printable version | Jul 7, 2022 12:20:27 pm | https://www.thehindu.com/opinion/editorial/the-litchi-link/article28022573.ece