Other States

How gender is determined in the brain

During prenatal development, the brains of most animals, including humans, develop specifically male or female characteristics. New research sheds light on how this process is triggered.

In the study, published in the journal Nature Neuroscience , Margaret McCarthy from the University of Maryland and colleagues studied brain development in newborn rats.

She found that giving estradiol, a testosterone derivative, triggers a mechanism by which certain genes in the brain are “unsilenced”, allowing them to initiate the process of masculinisation.

This process involves a group of enzymes known as DNA methyltransferases, or Dnmts, which modify DNA to repress gene expression.

The researchers also found that by inhibiting Dnmts, they could alter the reproductive behaviour of male and female mice.

In every species that has been studied, including humans, the POA plays a key role in governing male sexual behaviour.

The injections occurred after the first week of birth, the time when the window for brain sexual differentiation was thought to have been closed.

Despite this, the preoptic area in these animals was transformed, and took on structural characteristics of a male rat. — IANS

A letter from the Editor


Dear reader,

We have been keeping you up-to-date with information on the developments in India and the world that have a bearing on our health and wellbeing, our lives and livelihoods, during these difficult times. To enable wide dissemination of news that is in public interest, we have increased the number of articles that can be read free, and extended free trial periods. However, we have a request for those who can afford to subscribe: please do. As we fight disinformation and misinformation, and keep apace with the happenings, we need to commit greater resources to news gathering operations. We promise to deliver quality journalism that stays away from vested interest and political propaganda.

Support Quality Journalism
Recommended for you
This article is closed for comments.
Please Email the Editor

Printable version | Jun 3, 2020 8:52:35 AM | https://www.thehindu.com/news/national/other-states/how-gender-is-determined-in-the-brain/article7069323.ece

Next Story