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Govt. releases DRDO’s COVID drug for emergency use

Defence Minister Rajnath Singh hands over the first batch of 2-DG anti Covid drug to the Union Health Minister Harsh Vardhan, in New Delhi on May 17, 2021. Photo: Twitter/@rajnathsingh  

The first batch of the adjunct COVID therapy drug, 2-deoxy-D-glucose (2-DG) — developed by the Defence Research and Development Organisation (DRDO) along with Dr Reddy’s Laboratories (DRL), Hyderabad — was on Monday released for emergency use. Defence Minister Rajnath Singh formally handed over the drug to Health Minister Dr Harsh Vardhan.

“One box each of the sachets of the drug were handed over to Dr. Randeep Guleria, Director All India Institute of Medical Sciences (AIIMS) and Lt. Gen. Sunil Kant of Armed Forces Medical Services (AFMS). More will be handed over to different hospitals across the country for emergency use,” a Defence Ministry statement said.

An anti-COVID-19 therapeutic application of the drug 2-DG has been developed by Institute of Nuclear Medicine and Allied Sciences (INMAS), a DRDO lab along with DRL.

DRL will increase the production of the drug which is expected to be made available to all hospitals by the first week of June, said K. Satish Reddy, Chairman DRL.

The drug is a good example of DRDO and private partnership, which will help patients in overcoming oxygen dependency by around 40%, Mr. Singh said, speaking at the event. Dr. Harsh Vardhan said 2-DG was the first therapeutic drug for COVID which India has developed indigenously.

Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence, DRDO has said earlier adding, “Higher proportion of patients treated with 2-DG showed RT-PCR negative conversion in COVID patients.”

“Scientists have been working on the molecule for long and over the last one year clinical trials were conducted extensively in various hospitals across the country,” said Dr. G. Satheesh Reddy, Chairman DRDO.

On May 1, the Drugs Controller General of India (DCGI) granted permission for emergency use of this drug as adjunct therapy in moderate to severe COVID-19 patients, the DRDO announced last week.

Phase-II clinical trial of 2-DG in COVID-19 patients was approved by DCGI in May 2020 and Phase-III clinical trials were permitted in November 2020. The Phase-III clinical trial was conducted on 220 patients between December 2020 to March 2021 at 27 COVID hospitals in Delhi, Uttar Pradesh, West Bengal, Gujarat, Rajasthan, Maharashtra, Andhra Pradesh, Telangana, Karnataka and Tamil Nadu, DRDO had stated.


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Printable version | Jun 16, 2021 4:58:57 PM | https://www.thehindu.com/news/national/govt-releases-drdos-covid-drug-for-emergency-use/article34579529.ece

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