Conventional matching may not be a must for successful kidney transplantation

‘Presence of certain protein components in donor’s body enough to avoid rejection’

The success of a kidney transplantation depends on the matching of a particular protein in the donor’s body with that of the receiver, who are normally relatives. A new study has suggested that the mere presence of certain protein components in the donor’s body was enough to avoid a rejection of the organ and protein matching and being relatives may not be a must.

A research paper on this topic was presented at the ongoing conference of the Indian Botanical Society at Calicut University by T.A. Nidheesh Roy, full-time researcher attached to the Department of Biotechnology, on Wednesday.

Mr. Roy told The Hindu that matching of the human leukocyte antigens (HLA) was a key step in successful kidney transplantation. The quantity of these cell-surface proteins, responsible for the regulation of the immune system in human beings, could be different in human beings and their functioning too could be varied.

Chances of survival are higher if HLA are at least 90% identical in the body of the donor and receiver. Normally relatives are considered for organ donation. “Any cell with some other HLA type could be seen as an “invader” by the receiver’s immune system. It may lead to rejection of the tissue bearing those proteins that are on the surface of the cell. The transplanted organ will thus be rejected by the receiver’s body,” Mr. Roy said.

“To avoid the rejection, the donors can be selected on the basis of the presence of the real target of immune reaction in the HLA during renal transplantation. If there is a match between the protein targets, risks in the transplantation can be overcome. The donor and receiver can be unrelated,” Mr. Roy said.

The study titled ‘Protein docking studies with HLA in renal transplantation’ is done by Mr. Roy along with K.K. Elyas of the Department of Biotechnology and Feroz Aziz of the Department of Nephrology, MIMS Hospital, Kozhikode.

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Printable version | Feb 20, 2020 10:49:48 AM | https://www.thehindu.com/news/cities/kozhikode/conventional-matching-may-not-be-a-must-for-successful-kidney-transplantation/article29913003.ece

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