Defending champion Roger Federer was shown the door by Ukranian Sergiy Stakhovsky 6-7(5), 7-6(5), 7-5, 7-6(5) in the second round late on Wednesday.
It was Federer’s earliest exit at Wimbledon since 2002, when he was beaten in the first round. The Swiss' defeat is further good news for Britain's second seed Andy Murray.
Fifth seed and two-time champion Rafael Nadal was also on Murray's side of the draw but lost in the first round. Jo-Wilfried Tsonga, who was also in the bottom half, retired.