Stem cell therapy has been found useful in over 60 per cent of the patients due for liver transplant according to a paper submitted by doctors at Sir Ganga Ram Hospital here. Not only is the treatment less cumbersome and risky, its cost is also comparatively very reasonable.
According to the paper’s principal author and chairman of the Department of Gastroenterology and Liver Diseases at the hospital, Dr. Anil Arora, a large number of patients requiring liver transplantation cannot afford it for two reasons – cost and donor availability.
“A living donor is needed in such plantation cases with a matching blood group and he or she also has to be a family member or a first or second degree relative. They have to donate the liver. Since Rs.20 lakh is the average cost of liver transplantation, a majority of liver cirrhosis patients cannot afford it. Many times they also do not have a donor,” he says.
In view of the logistical problems faced by such patients, Dr. Arora says: “We started looking at the feasibility of alternative methods like using reserve cells in the body called stem cells for such treatment as it costs even less than Rs.50,000. Some of these cells can be mobilised from the bone marrow as it has the capacity to regenerate the cells. So we stimulate the bone marrow by an injection.”
“This injection is given for five days and it mobilises the bone marrow and some of the cells. They then come into the blood circulation. In the study we tried to filter these cells from the blood marrow using a specialised filtering machine and the concentrate of these cells. About 5 ml to 10 ml of the blood containing these concentrated groups of cells was then injected into the hepatic artery which supplies blood to the liver,” explains Dr. Arora. According to him, this process was carried out by different mechanisms and proved quite successful. “We started about two years ago and finished last year. Then these patients were followed up for another one year and we were happy to see a significant proportion of the patients having substantial improvement in the liver functions as assessed by a score called ‘Child score’.”
“All patients tolerated the treatment well without any side-effects. Of the 10 patients, six to seven benefited. So we believe that more frequent administration of the stem cells in large number might have a more beneficial impact,” he adds.
While the study by the Sir Ganga Ram Hospital team was published this year and approved by the Department of Biotechnology and the Union Ministry of Science & Technology, Dr. Arora says there is also other published data now which calls for “stimulating the bone marrow and letting the cells automatically go into the liver”. By this, he explains, you avoid filtering and putting the blood with the stem cells into the liver. “This is also equally beneficial.”
According to Dr. Arora, stem cell therapy “might act as a bridge for liver transplant” and can provide some time to the patients to arrange for treatment. But just like a damaged car tyre, he says, a damaged liver after minor repairs has to be replaced. “However, if a person stops taking liquor or if the therapy goes on well, then a patient can lead a healthy life for many more years.”