Scientists have shed light on the deadly Ebola virus’s mechanism of disrupting the immune system of patients, says a study.
Researchers have discovered the mechanism behind one of the Ebola virus’ most dangerous attributes: Its ability to disarm the adaptive immune system.
Scientists determined that Ebola short-circuits the immune system using proteins that work together to shut down cellular signalling related to interferon.
Disruption of this activity, researchers found, allows Ebola to prevent the full development of dendritic cells that would otherwise trigger an immune response to the virus.
“Dendritic cells typically undergo a process called “maturation” when they’re infected by a virus — they change shape and present antigens on their surface that tell T-cells to attack that particular virus, thus generating an adaptive immune response,” said Alexander Bukreyev, senior author. “But Ebola prevents dendritic-cell maturation and produces a severe infection without an effective adaptive immune response. We found that its ability to do this depends on several specific regions of two different proteins.”IANS
Ebola hemorrhagic fever kills up to 90 percent of its human victims within days of infection.