For David Moyes, the fixture list doesn’t get any easier. His first four league matches in charge of Manchester United included games against Chelsea and Liverpool - drawn and lost respectively - and on Sunday he faces the first Manchester derby since replacing Sir Alex Ferguson.
It’s too early to say defeat would be terminal to United’s title chances but, equally, to have just seven points from five games would give ammunition to those who doubt Moyes’s suitability for the job.
United have Wayne Rooney, now fit to play after suffering a gashed head, back in top form.
City are in a similar position, having won both their home games while losing at Cardiff City and drawing at Stoke City.
League leaders Liverpool host Southampton without winger Philippe Coutinho, who is sidelined for six weeks with a damaged shoulder.
Chelsea host Fulham in a west London derby, while Arsenal are a home to Stoke City and Tottenham Hotspur go to Cardiff City.DPA