A mechanical device that operates in the quantum realm tops the Science journal's list of advances in 2010.

Until this year, all human-made objects have moved according to the laws of classical mechanics. Back in March, however, a group of researchers designed a gadget that moves in ways that can only be described by quantum mechanics — the set of rules that governs the behaviour of tiny things like molecules, atoms, and subatomic particles. In recognition of the conceptual ground their experiment breaks, the ingenuity behind it and its many potential applications, Science has called this discovery the most significant scientific advance of 2010.

Physicists Andrew Cleland and John Martinis from the University of California at Santa Barbara and their colleagues designed the machine—a tiny metal paddle of semiconductor, visible to the naked eye — and coaxed it into dancing with a quantum groove.

First, they cooled the paddle until it reached its “ground state,” or the lowest energy state permitted by the laws of quantum mechanics (a goal long-sought by physicists).

Then they raised the widget's energy by a single quantum to produce a purely quantum-mechanical state of motion. They even managed to put the gadget in both states at once, so that it literally vibrated a little and a lot at the same time — a bizarre phenomenon allowed by the weird rules of quantum mechanics.

Science has recognized this first quantum machine as the 2010 Breakthrough of the Year.

They have also compiled nine other important scientific accomplishments from this past year into a top ten list, appearing in a special news feature in the journal's 17 December 2010 issue. “This year's Breakthrough of the Year represents the first time that scientists have demonstrated quantum effects in the motion of a human-made object,” said Adrian Cho, a news writer for Science. “On a conceptual level that's cool because it extends quantum mechanics into a whole new realm. On a practical level, it opens up a variety of possibilities ranging from new experiments that meld quantum control over light, electrical currents and motion to, perhaps someday, tests of the bounds of quantum mechanics and our sense of reality.”

The quantum machine proves that the principles of quantum mechanics can apply to the motion of macroscopic objects, as well as atomic and subatomic particles. It provides the key first step toward gaining complete control over an object's vibrations at the quantum level. Such control over the motion of an engineered device should allow scientists to manipulate those minuscule movements, much as they now control electrical currents and particles of light. In turn, that capability may lead to new devices to control the quantum states of light, ultra-sensitive force detectors and, ultimately, investigations into the bounds of quantum mechanics and our sense of reality. (This last grand goal might be achieved by trying to put a macroscopic object in a state in which it's literally in two slightly different places at the same time — an experiment that might reveal precisely why something as big as a human can't be in two places at the same time.)

“Mind you, physicists still haven't achieved a two-places-at-once state with a tiny object like this one,” said Cho. “But now that they have reached the simplest state of quantum motion, it seems a whole lot more obtainable—more like a matter of ‘when' than ‘if.'”

The other nine

Science's list of the nine other groundbreaking achievements from 2010 follows.

Synthetic Biology: In a defining moment for biology and biotechnology, researchers built a synthetic genome and used it to transform the identity of a bacterium. The genome replaced the bacterium's DNA so that it produced a new set of proteins—an achievement that prompted a Congressional hearing on synthetic biology. In the future, researchers envision synthetic genomes that are custom-built to generate biofuels, pharmaceuticals or other useful chemicals.

Neandertal Genome: Researchers sequenced the Neandertal genome from the bones of three female Neandertals who lived in Croatia sometime between 38,000 and 44,000 years ago. New methods of sequencing degraded fragments of DNA allowed scientists to make the first direct comparisons between the modern human genome and that of our Neandertal ancestors.

HIV Prophylaxis: Two HIV prevention trials of different, novel strategies reported unequivocal success: A vaginal gel that contains the anti-HIV drug tenofovir reduced HIV infections in women by 39 percent and an oral pre-exposure prophylaxis led to 43.8 fewer HIV infections in a group of men and transgender women who have sex with men.

Exome Sequencing/Rare Disease Genes: By sequencing just the exons of a genome, or the tiny portion that actually codes for proteins, researchers who study rare inherited diseases caused by a single, flawed gene were able to identify specific mutations underlying at least a dozen diseases.

Molecular Dynamics Simulations: Simulating the gyrations that proteins make as they fold has been a combinatorial nightmare. Now, researchers have harnessed the power of one of the world's most powerful computers to track the motions of atoms in a small, folding protein for a length of time 100 times longer than any previous efforts.

Quantum Simulator: To describe what they see in the lab, physicists cook up theories based on equations. Those equations can be fiendishly hard to solve. This year, though, researchers found a short-cut by making quantum simulators—artificial crystals in which spots of laser light play the role of ions and atoms trapped in the light stand in for electrons. The devices provide quick answers to theoretical problems in condensed matter physics and they might eventually help solve mysteries such as superconductivity.

Next-Generation Genomics: Faster and cheaper sequencing technologies are enabling very large-scale studies of both ancient and modern DNA. The 1,000 Genomes Project, for example, has already identified much of the genome variation that makes us uniquely human—and other projects in the works are set to reveal much more of the genome's function.

RNA Reprogramming: Reprogramming cells—turning back their developmental clocks to make them behave like unspecialized "stem cells" in an embryo—has become a standard lab technique for studying diseases and development.

This year, researchers found a way to do it using synthetic RNA. Compared with previous methods, the new technique is twice as fast, 100 times as efficient and potentially safer for therapeutic use.

The Return of the Rat: Mice rule the world of laboratory animals, but for many purposes researchers would rather use rats. Rats are easier to work with and anatomically more similar to human beings; their big drawback is that methods used to make "knockout mice"— animals tailored for research by having specific genes precisely disabled—don't work for rats. A flurry of research this year, however, promises to bring "knockout rats" to labs in a big way.

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