Why don't anti depressants work for many?

October 24, 2009 02:28 pm | Updated December 17, 2016 05:19 am IST - Washington

A new study has found powerful evidence that quashes the popular dogma that stress generally triggers depression. File photo: K. K. Mustafah

A new study has found powerful evidence that quashes the popular dogma that stress generally triggers depression. File photo: K. K. Mustafah

More than half the people who take anti-depressants seldom get relief. A new study says this is because drugs designed to treat depression aim at the wrong target.

The study led by Eva Redei, psychiatry professor at Northwestern University Feinberg School of Medicine (NUFSM), found powerful molecular evidence that quashes the popular dogma that stress generally triggers depression.

Her new research reveals that there is almost no overlap between stress-related genes and depression-related genes.

Her findings are based on extensive studies with a model of severely depressed rats that mirror many behavioural and physiological abnormalities found in patients with major depression.

“This is a huge study and statistically powerful,” Prof. Redei said. “This research opens up new routes to develop new anti-depressants that may be more effective. There hasn’t been an antidepressant based on a novel concept in 20 years.”

She took four genetically different strains of rats and exposed them to chronic stress for two weeks. Later, she identified genes in the brain regions (linked with depression in rats and human), that had increased or decreased in response to the stress in all four strains.

“This finding is clear evidence that at least in an animal model, chronic stress does not cause the same molecular changes as depression does,” said Prof. Redei, according to a NUFSM statement.

These findings were presented at a recent Neuroscience conference in Chicago.

0 / 0
Sign in to unlock member-only benefits!
  • Access 10 free stories every month
  • Save stories to read later
  • Access to comment on every story
  • Sign-up/manage your newsletter subscriptions with a single click
  • Get notified by email for early access to discounts & offers on our products
Sign in

Comments

Comments have to be in English, and in full sentences. They cannot be abusive or personal. Please abide by our community guidelines for posting your comments.

We have migrated to a new commenting platform. If you are already a registered user of The Hindu and logged in, you may continue to engage with our articles. If you do not have an account please register and login to post comments. Users can access their older comments by logging into their accounts on Vuukle.