Drug taken as a prophylactic reduces risk of HIV infection

November 24, 2010 11:38 pm | Updated 11:42 pm IST

WORD OF CAUTION: Pre-exposure prophylaxis should never be seen as the first line of defence against HIV

WORD OF CAUTION: Pre-exposure prophylaxis should never be seen as the first line of defence against HIV

An international trial, which has generated much excited anticipation, provides proof for the first time that pills used to treat HIV/AIDS can also prevent it. Campaigners greeted the results, published today in the New England Journal of Medicine , with enthusiasm, suggesting that they could fundamentally change the approach to preventing HIV in some groups of people.

The findings are good news for men who have sex with men, the population in whom the drugs were tried. There were 43.8 per cent fewer HIV infections among those who took Truvada, the once-a-day tablet containing two drugs, emtricitabine and tenofovir, than among those who did not.

The protective effect was much greater in those who took the tablets consistently: The study was carried out by the independent Gladstone Institute on behalf of the US National Institutes of Health in six countries: Brazil, Ecuador, Peru, South Africa, Thailand and the United States.

Nearly 2,500 men and transgender women who have sex with men and were at high risk of HIV infection took part in the study which began in 2007. Half the volunteers were given Truvada and the others were given a dummy pill.

Need for consistency

But Aids experts warned gay and bisexual men and their doctors that drugs did not offer an instant and easy answer. Protection was low in those who did not take them regularly.

The Centers for Disease Control and Prevention (CDC) in the United States issued guidance that pre-exposure prophylaxis “should never be seen as the first line of defence against HIV”.

Men who participated in the trials were counselled to use condoms, reduce their number of sexual partners and get tested and treated for other sexually transmitted diseases which can increase the risk of HIV infection.

The big unanswered question is whether drugs can also prevent infection in other at-risk groups, such as women in sub-Saharan Africa whose partners will not use condoms, and drug users.

Different routes

The study showed the pill is protective in sex between men, but it does not follow that drugs would protect during heterosexual sex, where the route of transmission is different.

Dr Kevin Fenton, director of the CDC National Centre for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, said the results “represent a major advance in HIV prevention research ... Given the heavy burden of HIV among gay and bisexual men, a new tool with potential additive benefit is exciting and welcome news.”

The findings provided hope that prophylactic drug treatment could protect other at-risk groups around the world. “Given the continued severity of the HIV epidemic, safe and effective new approaches are urgently needed for all populations at risk,” he said. — © Guardian Newspapers Limited, 2010

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