Philippine police have arrested four men and seized 1 billion pesos ($22 million) worth of methamphetamine in the second large drug bust in Manila in 10 days.

The National Police anti-illegal drugs task force said the men were driving a van filled with five wooden crates containing 200 kg (440 pounds) of crystal methamphetamine when they were stopped on Friday by police.

Last week, the National Bureau of Investigation arrested four Canadian men suspected of trafficking drugs from Mexico in separate raids on posh condominiums. Agents recovered 100 million pesos ($2.25 million) worth of cocaine, methamphetamine and MDMA, which is similar to Ecstasy.

Police said they were investigating an “unholy alliance” between Mexico’s Sinaloa cartel and Chinese drug syndicates operating in the Philippines.

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