When Aung San Suu Kyi last saw Europe, it was still divided into the democratic West and communist East. Her homeland of Myanmar was still under oppressive military rule.

The long-time democracy activist set out Wednesday on her first European trip since 1988 to make a long-awaited acceptance speech for the 1991 Nobel Peace Prize and at a time when Myanmar is making tenuous democratic progress.

Cheerful and energetic at Yangon’s airport, Ms. Suu Kyi waved to journalists and passengers as she headed to the departure lounge. Asked about her trip, Ms. Suu Kyi told reporters she expects it to be eye-opening.

“Each country will be different. I will know how backward (Myanmar) is when I reach the other countries,” Ms. Suu Kyi said.

For 24 years, the opposition leader was either under house arrest or too fearful that if she left Myanmar, the former military regime would not let her return. She stayed put even as her British husband was dying of cancer in England in 1999.

This will be Ms. Suu Kyi’s second overseas trip after a recent, five-day tour in Thailand and will be filled with high-profile events bound to burnish Ms. Suu Kyi’s image as an international political celebrity.

At her first stop in Geneva, Ms. Suu Kyi will address Thursday’s annual conference of the U.N.’s International Labour Organisation. Her next stop is Norway for what is expected to be an emotional acceptance speech of her Nobel prize, 21 years late.

She will briefly stop in Dublin to personally thank U2 frontman Bono for his support over the years. They will share the stage at a Monday concert in her honour organized by Amnesty International.

In England, Ms. Suu Kyi will receive the rare honour of addressing both houses of Britain’s parliament and will accept an honorary doctorate at Oxford, where she studied and later lived with her husband and sons, Alexander and Kim.

In April 1988, Ms. Suu Kyi left her family in England to nurse her dying mother back home.

The daughter of Myanmar’s independence hero Gen. Aung San, Ms. Suu Kyi got swept into the forefront of an uprising against the military regime. The junta viewed her popularity as such a threat that they locked her under house arrest for 15 of the next 22 years.

In November 2010, Ms. Suu Kyi was released from house arrest and in April she won a seat in Parliament, paving the way for Western nations to ease economic sanctions that had been imposed on the former military government.

One of Ms. Suu Kyi’s biggest challenges as she travels Europe will be to avoid upsetting the government, which has been praise for sweeping reforms but is still backed by the military.

Ms. Suu Kyi’s trip to Thailand reportedly irked President Thein Sein, due partly to the massive attention she received and also to the message she carried. At a speech to international investors and diplomats she warned against “reckless optimism” in Myanmar, saying the country still lacked the basic principles of a democracy.

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